Pathophysiology of Diabetic Ketoacidosis
Pathophysiology of Diabetic Ketoacidosis Diabetic ketoacidosis caused by lack of insulin or insufficient amount of insulin that is real, this situation led to disturbances in the metabolism of carbohydrates, proteins and fats. There are three important kliniks picture in diabetic ketoacidosis is dehydration, acidosis and electrolyte loss. If the amount of insulin is reduced, the amount of glucose that enters the cell will be reduced as well. Besides, the production of glucose by the liver becomes unmanageable. Both of these factors will result in hyperglycemia. In an effort to eliminate the excess glucose from the body, the kidneys excrete glucose together water and electrolytes (such as sodium and potassium). Osmotic diuresis which is characterized by excessive urination (polyuria) is the cause dehydration and electrolyte loss. Patients with severe ketoacidosis can lose approximately 6.5 liters of water and up to 400 to 500 mEq of sodium, potassium and chloride during a period of 24 h