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Showing posts from December 2, 2014

Clinical Manifestations of Cerebral Malaria

Malaria is clinically characterized by paroxysmal attacks of fever, and periodic, accompanied by anemia, enlargement of the spleen and sometimes with pernicious complications such as jaundice, diarrhea, black water fever, acute tubular necrosis, and cerebral malaria. In parasitology known 4 genus Plasmodium, the clinical characteristics of different forms of the fever, namely: Plasmodium vivax , clinically known as benign tertian malaria caused the fever attacks that arise every 3 days. Plasmodium malariae , also known clinically as well as Malaria Quartana arising because of the fever attacks every 4 days. Plasmodium ovale , clinically known as Malaria ovale, with no fever typical pattern every 2-1 days. Plasmodium falciparum , clinically known as Malaria tropicana or malignant tertian malaria causes the fever attacks which usually occur every 3 days with more severe symptoms than other species of plasmodium infection. Cerebral malaria is a severe complication of Plasmodium falciparum

3 Causes of Cerebral Malaria

The cause of cerebral malaria is Plasmodium falciparum infection. The basis of disease of Plasmodium falciparum infection is the process of hypoxia due to obstruction of blood vessels in the organ. The mechanism of obstruction can be through a series of events, namely cytoadherence , sequestration and rosetting . Cytoadherence is ripe PRBC attach to the surface of vascular endothelium. It is known that the Plasmodium falciparum infection PRBC has the power or ability attached to other cells, the endothelial cells of blood vessels and fellow erythrocytes infected or not infected. This mechanism only occurs in capillaries and post-capillary. Rosetting is a phenomenon of attachment between the PRBC with one or more non-parasitic erythrocytes. When the bond involves more than 10 erythrocytes (PRBC and non-PRBC), then shape so as flower (rosette), so that this phenomenon is referred to as the rosetting. Sequestration . Cytoadherence mechanism in capillaries and post-capillary will cau