Bilirubin Encephalopathy - Severe Neonatal Jaundice
Bilirubin is the main product of the decomposition of old red blood cells. Bilirubin is filtered from the blood by the liver, and excreted in the bile. As the liver becomes increasingly damaged, total bilirubin increases. Most of total bilirubin metabolized, and this section referred to as the direct bilirubin. When the sections are increased, the cause is usually outside the liver. If direct bilirubin is low while high total bilirubin, this indicates damage to the liver or bile duct in the liver. Bilirubin contain dyes that give color to the dirt. If the level is very high, the skin and eyes may be yellow , resulting in symptoms of jaundice. Severe neonatal jaundice and is not administered properly can cause complications bilirubin encephalopathy. This occurs due to the binding of bilirubin acid free with a cell wall lipids neurons in the basal ganglia, brain stem and cerebellum which leads to cell death. In infants with sepsis , hypoxia and asphyxia can cause damage to the blood-brai...