Pathophysiology of Varicella
Varicella is caused by the varicella-zoster virus. The disease is generally regarded as a mild, self-limiting viral illness with occasional complications. Varicella is common and highly contagious and affects nearly all susceptible children before adolescence. Although most varicella infection confers life-long immunity, varicella clinical reinfections among healthy children have been described.
Varicella, commonly known in the United States as chickenpox. Chickenpox is usually a benign disease in children, and almost all children recover uneventfully. However, varicella is not totally benign even today. A significant number of varicella cases are associated with complications, among the most serious of which are varicella pneumonia and encephalitis.
The virus enters the body through the mucosa of the upper respiratory tract / oropharynx that is the virus passes from one person to another through saliva sparks coming from coughing / sneezing patients and flown through the air and direct contact through infected skin.
Then the virus is experiencing the early multiplication of local and viruses that spread to the blood vessels and lymphatic channels (Viraemia Primary). Then it would be eaten by cells retikuloendotial system. Here occur more viral replication (in incubation period).
At this time, the infection is inhibited by non-specific immunity. In most individuals, viral replication is more prominent or more dominant than the immunity of his body, so that within 2 weeks after infection, viremia occurs more powerful (Viraemia Secondary).
This causes heat and malaise, as well as the virus spreads throughout the body via the bloodstream, mainly in the skin and mucous membranes.
Varicella, commonly known in the United States as chickenpox. Chickenpox is usually a benign disease in children, and almost all children recover uneventfully. However, varicella is not totally benign even today. A significant number of varicella cases are associated with complications, among the most serious of which are varicella pneumonia and encephalitis.
The virus enters the body through the mucosa of the upper respiratory tract / oropharynx that is the virus passes from one person to another through saliva sparks coming from coughing / sneezing patients and flown through the air and direct contact through infected skin.
Then the virus is experiencing the early multiplication of local and viruses that spread to the blood vessels and lymphatic channels (Viraemia Primary). Then it would be eaten by cells retikuloendotial system. Here occur more viral replication (in incubation period).
At this time, the infection is inhibited by non-specific immunity. In most individuals, viral replication is more prominent or more dominant than the immunity of his body, so that within 2 weeks after infection, viremia occurs more powerful (Viraemia Secondary).
This causes heat and malaise, as well as the virus spreads throughout the body via the bloodstream, mainly in the skin and mucous membranes.
