Pathophysiology of Osteoarthritis
Pathophysiology of Osteoarthritis
Degenerative joint disease is a chronic disease, not inflamed, and slowly progressive, which seemed to be an aging process, joint cartilage decline and degeneration accompanied by new bone growth at the edges of the joints.
The process of degeneration is caused by chondrocyte-solving process which is an important element of joint cartilage. Solving the allegedly initiated by certain biomechanical stress. Expenditure lysosomes causes dipecahnya polysaccharide enzyme proteins that form the matrix around chondrocytes resulting in cartilage damage. The joints most often affected are the joints that must bear weight, like knee and hip spine. Interfalanga distal joints and proksimasi.
Osteoarthritis in some cases will result in limited motion. This is caused by the pain suffered by or caused by narrowing of joint space or less use of these joints.
Degenerative changes that result because of certain events such as injury hinge joint infection and congenital deformity other arthritic diseases will cause trauma to the cartilage that is intrinsic and extrinsic ligaments causing existing fractures or joints metabolic changes that eventually lead to cartilage experience erosion and destruction, the bones become thick and occur narrowing of the joint cavity that causes pain, leg kripitasi, deformity, the presence of hypertrophy or nodulus.
Clinical Manifestations of Osteoarthritis
Degenerative joint disease is a chronic disease, not inflamed, and slowly progressive, which seemed to be an aging process, joint cartilage decline and degeneration accompanied by new bone growth at the edges of the joints.
The process of degeneration is caused by chondrocyte-solving process which is an important element of joint cartilage. Solving the allegedly initiated by certain biomechanical stress. Expenditure lysosomes causes dipecahnya polysaccharide enzyme proteins that form the matrix around chondrocytes resulting in cartilage damage. The joints most often affected are the joints that must bear weight, like knee and hip spine. Interfalanga distal joints and proksimasi.
Osteoarthritis in some cases will result in limited motion. This is caused by the pain suffered by or caused by narrowing of joint space or less use of these joints.
Degenerative changes that result because of certain events such as injury hinge joint infection and congenital deformity other arthritic diseases will cause trauma to the cartilage that is intrinsic and extrinsic ligaments causing existing fractures or joints metabolic changes that eventually lead to cartilage experience erosion and destruction, the bones become thick and occur narrowing of the joint cavity that causes pain, leg kripitasi, deformity, the presence of hypertrophy or nodulus.
Clinical Manifestations of Osteoarthritis
